Currently, any therapy that kills the ‘tricked’ fibroblast cells may
also kill fibroblasts throughout the body – for example in the bone
marrow and skin – causing toxicity.
So researchers used a virus called enadenotucirev, which is already in
clinical trials for treating carcinomas.
It has been bred to infect only cancer cells, leaving healthy cells
Lecturer Dr. Kerry Fisher also from the Department of Oncology who led
the research said: “Even when most of the cancer cells in a carcinoma
are killed, fibroblasts can protect the residual cancer cells and help
them to recover and flourish.”
“Our new technique to simultaneously target the fibroblasts while
killing cancer cells with the virus could be an important step towards
reducing immune system suppression within carcinomas and should
kick-start the normal immune process.”